Screening of the Alcohol Fraction of <i>Ferula akitschkensis</i> B. Fedtsch. ex Koso-Pol. by GC/MS Method

Introduction. Innovative technologies, new approaches to the creation of medicines, a combination classic technological methods with latest trends makes pharmaceutical production direction positive dynamics development. But along emergence synthetic drugs, as well biotech products, use herbal raw materials for medicines remains relevant. Phytopreparations have number undeniable advantages over drugs and are choice in different age groups, including preventive medicine. The flora Kazakhstan is distinguished by presence endemic plants sufficient source materials, which creates prerequisites their phytochemical profiling subsequent development phytopreparations. In this regard, Ferula akitschkensis B. Fedtsch. ex Koso-Pol., widespread Kazakhstan, accumulation various classes biologically active substances (flavonoids, coumarins, essential oils) has experience folk Aim. To study component composition ethanol extracts roots GC/MS using Wiley 7th edition, NIST’02 library predict pharmacological activity identified compounds PASS Online web resource Materials methods. Ethanol extraction was obtained 80 % ratio : extractant 1 10 under ultrasonic exposure at frequency 15–25 kHz 10–20 min, followed separation extract from meal. analyzed gas chromatography-mass spectrometry (GC/MS) full current scanning mode. mass spectra were interpreted edition libraries. biological compounds, used. Results discussion. Koso-Pol. characterized metabolomic profile that differs other members genus. Thus, o -cymene, oxygen derivative p -cymene – thymol 2,2'-methylenebis[6-(1,1-dimethylethyl)-4-methylphenol accumulate roots. These can form marker be used species identification within genus Ferula. prognostic evaluation showed an effect on metabolic biochemical processes, particular, proton potential mitochondrial membrane, catalysis, redox stabilization cell membranes. addition, antispasmodic, fibrinolytic, antioxidant activities predicted . And focus creating based Ferula, it advisable consider dermatological carminative drugs. Conclusion. Study GC-MS made possible establish derivatives 2,2'-methylenebis[6-(1,1-dimethylethyl)-4-methylphenol. make up identify since not main oil representatives Prediction silico possibility complex therapy means improving tissue respiration conditions accompanied violation processes body. It been shown medicinal candidates will fibrinolytic effects. may also scientific groups due anti-eczematous most ethanolic